ChemicalBook > CAS DataBase List > 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

Product Name
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CAS No.
412960-54-4
Chemical Name
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Synonyms
Eeyarestatin 1;Eeyarestatin I;Eeyarestatin I - CAS 412960-54-4 - Calbiochem;Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1;3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide;1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CBNumber
CB72518902
Molecular Formula
C27H25Cl2N7O7
Formula Weight
630
MOL File
412960-54-4.mol
More
Less

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Property

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL
form 
Light yellow-orange solid
pka
9.13±0.40(Predicted)
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1286
Product name
Eeyarestatin I
Purity
≥98% (HPLC)
Packaging
10mg
Price
$324
Updated
2024/03/01
Sigma-Aldrich
Product number
324521
Product name
Eeyarestatin I
Packaging
25mg
Price
$251
Updated
2024/03/01
Cayman Chemical
Product number
10012609
Product name
Eeyarestatin 1
Purity
≥98%
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
10012609
Product name
Eeyarestatin 1
Purity
≥98%
Packaging
10mg
Price
$105
Updated
2024/03/01
Cayman Chemical
Product number
10012609
Product name
Eeyarestatin 1
Purity
≥98%
Packaging
25mg
Price
$201
Updated
2024/03/01
More
Less

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Chemical Properties,Usage,Production

Uses

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation.

Biochem/physiol Actions

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.

storage

Store at +4°C

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Suppliers

EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58

412960-54-4, 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazideRelated Search:


  • 3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
  • Eeyarestatin I
  • Eeyarestatin 1
  • Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1
  • Eeyarestatin I - CAS 412960-54-4 - Calbiochem
  • 1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
  • 412960-54-4
  • C27H25Cl2N7O7